Incidence and Predictors of Sudden Cardiac Arrest in Sarcoidosis
| Autor: | Ashish Correa, Dhrubajyoti Bandyopadhyay, Birendra Amgai, David R. Okada, Kam Ho, Neel Patel, Bharat Narasimhan, Chayakrit Krittanawong, Rushil Shah, Davendra Mehta, Kirtipal Bhatia, Lingling Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Bundle branch block business.industry Sudden cardiac arrest Odds ratio 030204 cardiovascular system & hematology Logistic regression medicine.disease Sudden death Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Cardiology cardiovascular diseases 030212 general & internal medicine medicine.symptom business Electrocardiography Cause of death |
| Zdroj: | JACC: Clinical Electrophysiology. 7:1087-1095 |
| ISSN: | 2405-500X |
| Popis: | Objectives This study sought to identify electrocardiographic (ECG) and clinical predictors of sudden cardiac arrest (SCA) in sarcoidosis. Background Sudden cardiac death (SCD) is the leading cause of death in cardiac sarcoidosis (CS) and may be the earliest manifestation of disease. Widespread or repeated advanced imaging is a challenging solution to this problem. ECG is an affordable and widely accessible modality that could help guide diagnostic approaches and risk stratification. Methods Data were obtained from the National Inpatient Sample (2005–2017) using International Classification of Diseases-9th Revision and -10th Revision-Clinical Modification. The primary outcome was to identify predictors of SCA, whereas predictors of SCA in young individuals and those with normal ventricular function served as secondary measures. Furthermore, temporal trends in sarcoidosis as well as SCA were also analyzed. Logistic regression analysis was used to calculate odds ratios, following which a multivariable regression was used to adjust for potential confounders. Results Electrocardiographic markers of AV node dysfunction or bundle branch block are associated with substantially increased risk of SCA in a limited proportion of patients (8.6%). This association is also observed among younger patients ( Conclusions ECG evidence of AV nodal dysfunction or distal conduction disease should raise suspicion for cardiac involvement in patients with sarcoidosis and are associated with increased risk of SCA. ECG markers could help identify patients who would benefit from advanced imaging. The sensitivity of ECGs is, however, limited and presence of a normal ECG does not reflect a low risk of SCA. |
| Databáze: | OpenAIRE |
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