Effect of Molecular Weight and Degree of Acetylation on Adjuvantive Properties of Chitosan Derivatives
| Autor: | S. G. Markushin, I. I. Akopova, Inesa V. Blagodatskikh, S. N. Kulikov, A. V. Muranov, Vladimir E. Tikhonov, Igor A. Yamskov, Evgeniya A. Bezrodnykh |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Molecular mass Chemistry Immunogenicity 02 engineering and technology 021001 nanoscience & nanotechnology Applied Microbiology and Biotechnology Biochemistry Degree (temperature) Chitosan 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Acetylation Mole 0210 nano-technology Cytotoxicity |
| Zdroj: | Applied Biochemistry and Microbiology. 54:512-517 |
| ISSN: | 1608-3024 0003-6838 |
| DOI: | 10.1134/s0003683818050149 |
| Popis: | The hemostatic and immunostimulating activity and cytotoxicity were determined for a number of chitosans differing in molecular weight (from 3 to 510 kDa) and degree of acetylation (from 1 to 25 mol%) that were used as adjuvants in inactivated poliomyelitic, influenza, and live influenza vaccines. It has been shown that the hemostatic activity of chitosan increased sharply with an increase in its molecular weight. In oligochitosan with a molecular weight of |
| Databáze: | OpenAIRE |
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