A two-region transport model for interpreting T1-T2 measurements in complex systems
| Autor: | Joseph D. Seymour, Sarah L. Codd, James E. Maneval, Linn W. Thrane, Madison L. Nelson |
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| Rok vydání: | 2019 |
| Předmět: |
Nuclear and High Energy Physics
Materials science Biophysics Physical system Complex system Microporous material Eigenfunction 010402 general chemistry Condensed Matter Physics 01 natural sciences Biochemistry Molecular physics Signal 030218 nuclear medicine & medical imaging 0104 chemical sciences 03 medical and health sciences Coupling (physics) 0302 clinical medicine Normal mode Time domain |
| Zdroj: | Journal of Magnetic Resonance. 308:106592 |
| ISSN: | 1090-7807 |
| Popis: | A 1D two region coupled pore model with discrete pore coupling is developed to elucidate the eigenmode interactions in regions with different surface relaxivity. Numerical solution of the model and simulation of the correlation experiment for varying surface relaxivity, pore connectivity and pore size ratio indicate the role of negative eigenmodes and overlap of T 1 and T 2 eigenmodes in generating a time domain signal increase with inversion recovery time, t 1 . The eigenmodes and eigenfunctions are considered in detail providing connection between the mathematical model and the diffusion dynamics and spin physics of the system. Physical systems, i.e. a microporous glass bead pack, a cyclopentane/water hydrate former, and beeswax, showing experimentally measured T 1 - T 2 time domain signal rise are considered within the limitations of the model. |
| Databáze: | OpenAIRE |
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