An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug

Autor:	Satish Kumar Vujjini, Mukkanti Kagga, Srinivas Arevelli, Satyanarayana Raju Tirumalaraju, Sreenatha Charyulu Kandala, Rakeshwar Bandichhor, Praveen Cherukupally, Ganesh Varanasi
Rok vydání:	2013
Předmět:	Computer science business.industry Manufacturing process Process (engineering) Antineoplastic drug Organic Chemistry Scalability Physical and Theoretical Chemistry Process engineering business
Zdroj:	Organic Process Research & Development. 17:303-306
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op300192e
Popis:	An improved, practical, and scalable process for the manufacture of antineoplastic drug, 5-azacytidine (1), is described. A thorough understanding of the reaction parameters and stability of the reaction intermediates led us to the development of a robust process. The challenges in the isolation and systematic approach used to streamline the process into a very robust and practical manufacturing process are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::73ca57b0c8b53786e0f43062f3e4beb6 https://doi.org/10.1021/op300192e Zobrazit plný text záznamu