| Autor: |
Stefano Geuna, Marcel F. Meek, Michele Fornaro, Artur S.P. Varejão, António M. Cabrita, Maria G. Giacobini-Robecchi |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Microsurgery. 23:338-345 |
| ISSN: |
0738-1085 |
| DOI: |
10.1002/micr.10147 |
| Popis: |
Previous morphological and morphometrical studies showed that fresh-skeletal-muscle-enriched vein segments are good conduits for leading peripheral nerve regeneration. In the present study, we investigated the morphological features of peripheral nerve fibers regenerated along a 10-mm-long biodegradable poly (DLLA-ϵ-CL) nerve guide enriched with fresh skeletal muscle, comparing them to nerve fiber regeneration along 10-mm-long phosphate-buffered saline (PBS)-enriched poly (DLLA-ϵ-CL) tubes. Repaired nerves were analyzed at weeks 6 and 24 postoperatively. Structural and ultrastructural observation showed that good nerve fiber regeneration occurred in both PBS-enriched and fresh-skeletal-muscle-enriched nerve guides, and histomorphometrical analysis of regenerated myelinated fibers revealed no statistically significant differences between the two experimental groups at week 24 after surgery. The employment of fresh-muscle-enriched conduits for the repair of nerve defects is critically discussed in the light of these results. © 2003 Wiley-Liss, Inc. MICROSURGERY 23:338–345 2003 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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