An improved microfluidic device to enhance the enrichment factors in liquid phase microextraction: application to the simultaneous extraction of polar and non-polar acids in biological samples

Autor: Alejandro Martín, Rut Fernández-Torres, Miguel Ángel Bello-López, María Ramos-Payán
Rok vydání: 2023
Předmět:
Zdroj: Microchimica Acta. 190
ISSN: 1436-5073
0026-3672
Popis: A new microfluidic device to enhance the enrichment factor in miniaturized systems is proposed. The microfluidic system was design for liquid phase microextractions, and it was applied to the simultaneous extraction of acidic compounds of a wide range of polarity (0.5 P −1 for all compounds at 10 µL min−1 as donor flow rate and 20-min extractions, offering EFs between 11 and 18 with only 200-µL sample volume consumption. The method was successfully applied to human urine samples, observing recoveries between 47 and 90% for all compounds. This new proposed microfluidic system increases the wide range of applications, especially when the analytes are present in lower concentrations in the sample. Graphical Abstract
Databáze: OpenAIRE
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