Effect of antibodies and complement on the interaction between escherichia coli 0111:B4 and polymorphonuclear leukocytes

Autor:	Francesco Tedesco, Franca Cian, Pierluigi Patriarca, G. D. Rottini, G. de Nicola
Rok vydání:	1979
Předmět:	Microbiology (medical) Strain (chemistry) biology Phagocytosis General Medicine medicine.disease_cause Complement system Complement (complexity) Microbiology Infectious Diseases biology.protein medicine Alternative complement pathway Ingestion Antibody Escherichia coli
Zdroj:	Infection. 7:160-165
ISSN:	1439-0973 0300-8126
DOI:	10.1007/bf01640933
Popis:	The interaction ofEscherichia coli 0111:B4 with polymorphonuclear leukocytes in the presence of specific antibodies and complement was studied. This strain, which is resistant to phagocytosis by polymorphonuclear leukocytes, may be ingested and killed by the phagocytes in the presence of both antibodies and fresh serum. The ineffectiveness of fresh serum to promote ingestion ofE. coli 0111:B4 by the phagocytes in the absence of antibodies reflects the inability of this strain to activate the complement system through the alternative pathway. Investigation of the mechanisms of the bacterial killing by polymorphonuclear leukocytes showed that both antibodies and complement were required for the oxygen-independent bactericidal system, whereas they were not needed for the oxygen-dependent system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::73b99d3b9a02c4de804a5a64911a1699 https://doi.org/10.1007/bf01640933 Zobrazit plný text záznamu Full text from SpringerLink