Steroidal saponins and homoisoflavanone from the aerial parts of Sansevieria cylindrica Bojer ex Hook
| Autor: | Farouk R. Melek, Gehad A. Abdel Jaleel, Elsayed A Aboutabl, Ataa Said, Mona A. Raslan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Antioxidant biology Chemistry Stereochemistry DPPH medicine.medical_treatment Saponin Plant Science biology.organism_classification Ascorbic acid Biochemistry Human tumor chemistry.chemical_compound Phytochemical Sansevieria cylindrica medicine Cytotoxicity Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 12:113-118 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2015.03.006 |
| Popis: | Phytochemical study on the methanolic extract of Sansevieria cylindrica aerial parts lead to the isolation, characterization and structure elucidation of a new steroidal saponin, 1β-hydroxy-kryptogenin-1- O -α- l -rhamnopyranosyl-(1 → 2)-α- l -arabinopyranoside ( 1 ), a new homoisoflavanone, (3S)-3,7-dihydroxy-8-methoxy-3-(3′,4′-methylenedioxybenzyl) chroman-4-one ( 2 ) and the known saponin alliospiroside A ( 3 ). To the best of our knowledge, the genin 1β-hydroxy-kryptogenin is reported here for the first time. The structures of the new compounds were determined by UV, IR, EIMS, HRESIMS together with 1D ( 1 H and 13 C) and 2D (HSQC and HMBC) NMR spectral analysis. The isolated compounds 1–3 were tested for their radical scavenging activity (DPPH). Compound 2 exhibited activity compared to that of ascorbic acid as a standard. The cytotoxicity of the isolated compounds and the standard doxorubicin was tested against the three human tumor cell lines HT116, MCF-7 and PC-3. The results showed that the isolated compounds were inactive. |
| Databáze: | OpenAIRE |
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