Identification and Synthesis of an Oxidation Product of Tilmicosin
| Autor: | Robin S. Readnour, James Patrick Leeds, K. E. Willard, Douglas E. Kiehl, Christine M. Cleveland, Herbert A. Kirst, Paul R. Klink |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Double bond Stereochemistry Epoxide General Chemistry Nuclear magnetic resonance spectroscopy Mass spectrometry Combinatorial chemistry chemistry.chemical_compound chemistry Product (mathematics) Molecule Tilmicosin General Agricultural and Biological Sciences Antibacterial agent |
| Zdroj: | Journal of Agricultural and Food Chemistry. 46:3265-3271 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf9710746 |
| Popis: | During formulation development of the veterinary macrolide antibiotic tilmicosin, an oxidation product of the parent molecule was identified. Use of liquid chromatography/mass spectrometry and nuclear magnetic resonance spectroscopy characterized the structure as 12,13-epoxytilmicosin, resulting from the oxidation of the double bond at the 12,13-position of the macrolide dienone. The synthesis of this oxidation product for confirmation of structural identity is described. The synthetic compound was identical to the isolated oxidation product, 12,13-epoxytilmicosin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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