Inhibitory effect of CCA on immunoglobulin-production induced by B 151-TRF2
| Autor: | Kazumi Urakawa, Toshiyuki Hamaoka, Shinya Murakami, Yasuhisa Takeda, Shiro Ono, Yutaka Sugawara, Fumiya Hirayama, Yoshiyuki Ohsugi, Keiko Nakamura, Akemi Sakamoto, Masahiko Mihara, Toshiaki Nakano |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Autoimmune disease
biology business.industry fungi information science Autoantibody Stimulation medicine.disease Inhibitory postsynaptic potential Molecular biology In vitro Polyclonal antibodies parasitic diseases Immunology cardiovascular system medicine biology.protein cardiovascular diseases Antibody business Inhibitory effect |
| Zdroj: | Ensho. 10:465-469 |
| ISSN: | 1884-4006 0389-4290 |
| DOI: | 10.2492/jsir1981.10.465 |
| Popis: | Lobenzarit disodium (CCA) is an immunomodulating anti-rheumatic drug, and is reported to show inhibitory effects on B-cell activation. To further analyze the direct effects of CCA on B cells, we examined the effects of CCA on Ig-production in vitro by murine B cells stimulated with murine T cell-derived B-cell stimulation factor, B 151-TRF 2 which induces a polyclonal differentiation into Ig-secreting cells including autoantibody production.CCA inhibited Ig-production induced by B 151-TRF 2. This result suggests that the inhibitory effect of CCA on Ig-production is one of the mechanism of CCA action on autoimmune disease, because B 151-TRF 2 is reported to be closely associated with the onset of autoimmune disease. In contrast, CCA did not inhibit Ig-production induced by LPS.These results demonstrate that the induction process of Ig-production by B 151-TRF 2 is differ from that of Ig-production by LPS, and that the effective point of CCA is associated with this difference. |
| Databáze: | OpenAIRE |
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