The control of release probability at nerve terminals
| Autor: | Jeremy S. Dittman, Timothy A. Ryan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemistry General Neuroscience Cell Lipid bilayer fusion Secretory Vesicle Synaptic vesicle Exocytosis Synaptic vesicle fusion Cell biology 03 medical and health sciences Probabilistic process 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Extracellular medicine 030217 neurology & neurosurgery |
| Zdroj: | Nature Reviews Neuroscience. 20:177-186 |
| ISSN: | 1471-0048 1471-003X |
| Popis: | Exocytosis is a fundamental membrane fusion process by which the soluble or membrane-associated cargoes of a secretory vesicle are delivered to the extracellular milieu or the cell surface. While essential for all organs, the brain relies on a specialized form of exocytosis to mediate information flow throughout its vast circuitry. Neurotransmitter-laden synaptic vesicles fuse with the plasma membrane on cue with astonishing speed in a probabilistic process that is both tightly regulated and capable of a fascinating array of plasticities. Here, we examine progress in the molecular understanding of synaptic vesicle fusion and its control. |
| Databáze: | OpenAIRE |
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