Melatonin: A Rediscovered Antitumor Hormone? Its Relation to Surface Receptors; Sex Steroid Metabolism, Immunologic Response, and Chronobiologic Factors in Tumor Growth and Therapy
| Autor: | William Regelson, W. Pierpaoli |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty Diurnal temperature variation General Medicine Biology Melatonin Pineal gland Endocrinology medicine.anatomical_structure Oncology Dark therapy Sex steroid Internal medicine medicine Circadian rhythm Receptor hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Cancer Investigation. 5:379-385 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.1080/07357908709170112 |
| Popis: | Melatonin (5-methoxy-N-acetyltryptamine) is a lipidsoluble derivative of 5-hydroxytryptamine, which is produced clinically via the pineal gland under the influence of sympathetic neural tone governed by diurnal variation in light exposure. Melatonin secretion is maximal with the onset of darkness and it controls diurnal rhythms (i.e., temperature and sleep) and the seasonal Zeitgebar involving reproductive behavior, the seasonal pelt, and pigmentation. The complicated patterns of these relationships between pituitary-hypophyseal, light exposure, and the pineal gland that may be mediated by melatonin have been discussed in a number of reviews (1-13). These observations have resulted in a recent conference on melatonin in humans (14) where melatonin diurnal and seasonal rhythms have been shown to be a factor in sleep and seasonal affective disorders. Recent observations suggest that melatonin deserves clinical trial to enhance or modify response in hormonally sensitive tumors and to determine if melatonin’s impact on chronobiologic control can improve the circadian |
| Databáze: | OpenAIRE |
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