Synthesis and hydrazinolysis of β-(1,3,4-oxadiazol-2-yl)pyridines

Autor:	A. S. Pugachova, M. V. Voevudsky, Vladimir I. Musatov, O. V. Krischik, O. U. Nesterova
Rok vydání:	2011
Předmět:	Acylation chemistry.chemical_compound chemistry Orthoformic acid Boiling Organic Chemistry Hydrazine Organic chemistry Hydrate Hydrazide
Zdroj:	Chemistry of Heterocyclic Compounds. 46:1520-1526
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-011-0702-7
Popis:	Cyclization of the hydrazide of 5-ethoxycarbonyl-2,6-dimethylpyridine-3-carboxylic acid by acylation with aromatic or aliphatic acid chlorides with subsequent boiling in POCl3 or heating in orthoformic acid gave the corresponding ethyl 2,6-dimethyl-5-(5-R-1,3,4-oxadiazol-2-yl)pyridine-3-carboxylate. The cyclization of the reaction products with hydrazine hydrate has been studied. Cyclization of the dihydrazide of 2,6-dimethyl-3,5-pyridinedicarboxylic acid under analogous conditions gave only 3,5-bis-(5-R-1,3,4-oxadiazol-2-yl)-2,6-dimethylpyridines, containing R = 2-FC6H4, H.
Databáze:	OpenAIRE
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