In-Silico Analysis of the Binding Affinity of 1-DNJ Compound from Mulberry Plant Against Caries Causing Enzymes

Autor:	Dhananjaya G, Sylvia Mathew, Deveswaran Raja, Parasuram P
Rok vydání:	2022
Zdroj:	ECS Transactions. 107:17681-17689
ISSN:	1938-6737 1938-5862
Popis:	Dental caries is a chronic disease and is unique among humans and is caused due to the accumulation of biofilm, which is characterized by microbial activity. Streptococcus mutans releases enzymes like SortaseA, which play an important role in the adhesion of bacteria to the tooth surface. Mulberry, a natural product has shown anti-cariogenic activity, which may be because of various compounds present in the plant extract. One such compound is 1-DNJ, an alkaloid shown to suppress S.mutans. In the last few decades, docking analysis has been used to get an insight into mechanism of action of test compounds. In the present study, we explored to analyze the in-silico interaction of 1-DNJSortaseA complex and found the compound to be effective in the inhibition of adherence of S.mutans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7398428b60531ec028b69f4a97a9a096 https://doi.org/10.1149/10701.17681ecst Zobrazit plný text záznamu