Experimental myocardial infarction in calves
| Autor: | William E. Elzinga, Robert B. Schultz |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
business.industry Coronary embolization Vessel occlusion General Medicine medicine.disease Left coronary artery Single bolus Internal medicine medicine.artery Anesthesia Coronary vessel Occlusion medicine Cardiology Surgery Myocardial fibrosis Myocardial infarction business |
| Zdroj: | The American Journal of Surgery. 121:593-599 |
| ISSN: | 0002-9610 |
| Popis: | Two technics to induce coronary vessel occlusion were combined to develop an animal model of myocardial infarction that closely simulates human heart disease. Plastic microspheres (25 to 55 μ) were first injected into the left coronary artery to produce generalized myocardial fibrosis. This procedure was followed by massive and localized myocardial infarction induced by the coronary magnet and iron particle technic. Two methods of plastic microsphere injection were studied: the “single bolus” technic and the slow infusion technic. The single bolus technic of plastic microsphere injection (dose range from 2.77 to 0.22 mg/kg) produced severe depression of myocardial contractile activity and usually resulted in immediate death of the animal. Slow infusion of a diluted suspension of plastic microspheres (1 mg/cc) into the left coronary artery greatly reduced the mortality and permitted infusion of up to 2.1 mg/kg of body weight. Iron inoculations into the animals produced from 5 to 100 per cent occlusion of the vessel at the level of the magnet. The combination of the two technics produced extensive myocardial damage in the calf heart. |
| Databáze: | OpenAIRE |
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