| Autor: |
Anatoly N. Varaksin, E. V. Shishkina, I. E. Valamina, Boris A. Katsnelson, Larisa I. Privalova, Ekaterina Y. Meshtcheryakova, V. B. Gurvich, Vladimir G. Panov, Ilzira A. Minigalieva, O. G. Makeyev, Vladimir Ya. Shur, S. V. Solovyeva, Svetlana V. Klinova, Marina P. Sutunkova |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Toxicological Review. :18-27 |
| ISSN: |
0869-7922 |
| Popis: |
Stable suspensions of metal/metalloid oxide nanoparticles (MeO-NPs) obtained by laser ablation of 99.99% pure elemental aluminum, titanium or silicon under a layer of deionized water were used separately or in different combinations to induce subchronic intoxications in rats. To this end, MeO-NPs had been repeatedly injected intraperitoneally (i.p.) 18 times during 6 weeks before a large number of functional, biochemical and morphometric indexes for the organism’s status were measured. It was found that, in many respects, the Al2O3-NPs were the most toxic as such and the most dangerous component of the studied combinations. Mathematical modeling with the help of the Response Surface Methodology has shown that the response of the organism to a simultaneous exposure to any two of the MeO-NPs under study is characterized by all possible types of combined toxicity (additivity, subadditivity or superadditivity of unidirectional action and different variants of opposite effects) depending on which outcome this type is estimated for as well as on the levels of the effect and dose. With any third MeO-NP species acting in the background, the type of combined toxicity displayed by the other two can change significantly. Many adverse effects produced by the [Al2O3-NP+TiO2-NP+SiO2-NP]-combination, including its genotoxicity, were substantially attenuated by giving to rats per os during the entire exposure period complex of innocuous bioprotective substances. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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