The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility

Autor: Enrique Gonzalez, Racquel Sanchez, Brad H. Rovin, Luisa Sen, Stephanie A. Anderson, Robert J. B. Nibbs, Rosa Bologna, Brian K. Agan, Andrea Mangano, Gabriel Catano, Sunil K. Ahuja, Matthew J. Dolan, Krishna K. Murthy, William E. Bradley, Seema S. Ahuja, Robert J. O'Connell, Robert A. Clark, Hemant Kulkarni, Hector Bolivar, Barry I. Freedman, Marlon P. Quinones, Michael J. Bamshad
Rok vydání: 2005
Předmět:
Zdroj: Science. 307:1434-1440
ISSN: 1095-9203
0036-8075
DOI: 10.1126/science.1101160
Popis: Segmental duplications in the human genome are selectively enriched for genes involved in immunity, although the phenotypic consequences for host defense are unknown. We show that there are significant interindividual and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1αP), a potent human immunodeficiency virus–1 (HIV-1)–suppressive chemokine and ligand for the HIV coreceptor CCR5. Possession of a CCL3L1 copy number lower than the population average is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This susceptibility is even greater in individuals who also possess disease-accelerating CCR5 genotypes. This relationship between CCL3L1 dose and altered HIV/AIDS susceptibility points to a central role for CCL3L1 in HIV/AIDS pathogenesis and indicates that differences in the dose of immune response genes may constitute a genetic basis for variable responses to infectious diseases.
Databáze: OpenAIRE
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