An iron–carboxylate-based metal–organic framework for Furosemide loading and release
| Autor: | Felycia Edi Soetaredjo, Suryadi Ismadji, Yi-Hsu Ju, Wenny Irawaty, Ignatius Ang, Phuong Lan Tran-Nguyen, Sandy Budi Hartono, Artik Elisa Angkawijaya, Maria Yuliana, Shella Permatasari Santoso, Yanita Devi |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Molar concentration Scanning electron microscope 020502 materials Mechanical Engineering Langmuir adsorption model 02 engineering and technology Thermogravimetry Solvent chemistry.chemical_compound symbols.namesake 0205 materials engineering chemistry Mechanics of Materials symbols General Materials Science Carboxylate Drug carrier Nuclear chemistry BET theory |
| Zdroj: | Journal of Materials Science. 55:13785-13798 |
| ISSN: | 1573-4803 0022-2461 |
| Popis: | An iron–carboxylate-based metal–organic framework, Fe-MIL100, has been synthesized using acid-free solvent at room temperature. Fe-MIL100 was prepared by combining Fe/H3BTC/NaOH/H2O (H3BTC = trimesic acid) at a molar ratio of 1.5:1.0:x:880, where x is the varied NaOH concentration at 1.5, 3.0, and 5.0 M. The effect of NaOH molar concentration on the formation of Fe-MIL100 was studied. Characterizations of the Fe-MIL100 were carried out using powder X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen (N2) adsorption–desorption, and thermogravimetry analysis (TGA). The obtained Fe-MIL100, with x NaOH of 3.0 M, has an octahedral crystal shape (a = 73.41 A), crystal size ranging from 100 to 400 nm, BET surface area of 1,446.4 m2/g, a pore volume of 0.829 cm3/g, and thermal degradation temperature of 358 °C. The potential of Fe-MIL100, a drug carrier device, was tested against Furosemide (a loop diuretic). As studied using the Langmuir adsorption isotherm model, 392.4 mg of Furosemide can be loaded per g of Fe-MIL100. The kinetic release of Furosemide was examined at 2 different biological pH of 5.8 and 7.4. The release profile of Furosemide was recorded within 24 h; it was found that the release profile follows the pseudo-first-order kinetics at pH 5.8 with a percent cumulative release of 41.56% and Korsmeyer–Peppas model at pH 7.4 with a percent cumulative release of 68.46%. The electrostatic repulsion drove the release of Furosemide from Fe-MIL100 due to the same negative charge of the compounds. Fe-MIL 100 at low concentration ( |
| Databáze: | OpenAIRE |
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