A Short Synthesis of Carbazole Alkaloids - Ekeberginine, Murrayaquinone a and Glycozoline

Autor: Aadil A. Momin, Tukaram D. Urmode, Shrikar M. Bhosale, Kusurkar, Radhika S.
Rok vydání: 2016
DOI: 10.6084/m9.figshare.3408013.v1
Popis: Three differently substituted naturally occurring, biologically active carbazole derivatives viz. ekeberginine, murrayaquinone A and glycozoline were synthesized in good yield using short and simple routes. Prenyl group was selectively introduced at C4 position using Stille coupling reaction in the synthesis of ekeberginine. Murrayaquinone A was synthesized using Raney nickel mediated desulfurization of dithiane as a key step. Synthesis of glycozoline was achieved in two steps from 3-methyl carbazole via an intermediate 3-bromo-6-methyl carbazole.
Databáze: OpenAIRE