Transient thrombopoietin peak after liver transplantation for end-stage liver disease
| Autor: | U. E. Nydegger, S. P. Hauser, M. Faeh |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Alcoholic liver disease
medicine.medical_specialty Cirrhosis business.industry medicine.medical_treatment Hematology Hepatitis C Liver transplantation Hepatitis B medicine.disease Gastroenterology Transplantation Primary biliary cirrhosis Internal medicine Immunology medicine business Thrombopoietin |
| Zdroj: | British Journal of Haematology. 112:493-498 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2001.02567.x |
| Popis: | Knowledge about synthesis of thrombopoietin (TPO) by human liver cells is now well established and makes the study of TPO serum levels and interdependency with platelet concentrations important before and after liver transplantation. We followed these variables in 14 patients suffering from primary biliary cirrhosis (group A), 10 with hepatitis B (group B) and nine with hepatitis C (group C) infections, as well as 11 patients suffering from alcoholic cirrhosis (group D). In the pretransplant serum samples. TPO levels and platelet counts revealed median values (range) of 112.75 pg/ml (5.0-349.3) in group A. 67.8 pg/ml (14.8-249.9) in B, 68.6 pg/ml (31.4-147.3) in C and 57.9 pg/ml (25.2-264.2) in D for TPO, and 138 × 10 9 /I (36-243) in A. 48 x 10 9 /l (22-129) in B, 105 x 10 9 /l l (32-176) in C and 109 × 10 9 /l (33-285) in D for platelets. the latter levels being abnormally reduced. Within 2-3 d of transplantation, the TPO levels started to increase to transient peaks of mostly 5-10 times baseline, which were followed by continuous correction of thrombocytopenia. Splenomegaly was identified to be an important co-factor of thrombocytopenia in groups A and D. We conclude that decreased TPO production in patients with end-stage liver diseases is reverted by orthotopic liver transplantation. |
| Databáze: | OpenAIRE |
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