| Autor: |
Buyinza, Daniel, Yang, Li Jun, Derese, Solomon, Ndakala, Albert, Coghi, Paolo, Heydenreich, Matthias, Wong, Vincent Kam Wai, Möller, Heiko M., Yenesew, Abiy |
| Rok vydání: |
2019 |
| DOI: |
10.6084/m9.figshare.9778439.v1 |
| Popis: |
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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