Increased serum triglyceride clearance, unchanged cholesteryl ester transfer protein activity, and elevated HDL cholesterol during treatment of hypertriglyceridemia with bezafibrate
| Autor: | Nagahiko Sakuma, Takeshi Hibino, Nobuyuki Ohte, Junichiro Hayano, Reiko Ikeuchi, Takaaki Sato, Yoshinobu Kamiya, Masanobu Kawaguchi |
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| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
Apolipoprotein E medicine.medical_specialty Bezafibrate Apolipoprotein B biology Triglyceride Cholesterol business.industry Hypertriglyceridemia Lipid metabolism medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Cholesterylester transfer protein medicine biology.protein lipids (amino acids peptides and proteins) Pharmacology (medical) business medicine.drug |
| Zdroj: | Current Therapeutic Research. 55:1223-1231 |
| ISSN: | 0011-393X |
| DOI: | 10.1016/s0011-393x(05)80263-2 |
| Popis: | The effects of bezafibrate on lipid metabolism were evaluated in 22 patients with type IIb or type IV hypertriglyceridemia. Bezafibrate 400 mg/d was administered for 8 weeks. A fat emulsion tolerance test (FETT) to evaluate serum triglyceride (TG) clearance (fractional removal rate = K2) and measurement of cholesteryl ester transfer protein (CETP) activity were performed before bezafibrate administration and after the 8-week treatment period using blood samples obtained after overnight fasting. Statistically significant reductions were observed in serum TG (P < 0.01), apolipoprotein (apo) B (P < 0.01), apo C-II (P < 0.05), apo C-III (P < 0.001), and apo E (P < 0.05). Significant increases were seen in high-density lipoprotein cholesterol (HDL-C) (P < 0.001), apo A-I (P < 0.001), and apo A-II (P < 0.001). K2 was significantly elevated (P < 0.001). CETP activity declined slightly, but the change was not statistically significant. Strong positive correlations were evident between the absolute value of increased K2 and the increase in both HDL-C (r = .67, P < 0.005) and apo A-I (r = .53, P < 0.05). It can be inferred from these findings that the bezafibrate-induced reduction in serum TG and increase in HDL-C observed in patients with hypertriglyceridemia arise from an acceleration in TG-rich lipoprotein metabolism. |
| Databáze: | OpenAIRE |
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