Chondroradionecrosis of the larynx: 24-year University of Wisconsin experience
| Autor: | Christopher J. Britt, Paul M. Harari, Gregory K. Hartig, Thomas Gessert, Austin M. W. Maas, Aaron M. Wieland |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Larynx
medicine.medical_specialty business.industry General surgery medicine.medical_treatment Medical record Head neck Cancer medicine.disease Cancer recurrence Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology Salvage radiation 030220 oncology & carcinogenesis medicine 030223 otorhinolaryngology Complication business |
| Zdroj: | Head & Neck. 39:1189-1194 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.24749 |
| Popis: | Background Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence. Methods Two hundred ninety-four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN. Results Of the 294 patients, 7 cases (2.4%) of CRN were identified. Development of CRN was associated with the presence of cartilage invasion by tumor (p = .038) and ongoing alcohol use postradiotherapy (p = .036). Additionally, a trend between development of CRN and ongoing smoking postradiotherapy was observed (p = .067). Conclusion The diagnosis of CRN is challenging, and the likelihood of successful resolution is modest. A high premium should be placed on efforts directed at prevention, such as tobacco and alcohol cessation. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1189–1194, 2017 |
| Databáze: | OpenAIRE |
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