Autor: |
Daniel L. Dexter, Jean C. Hager, Frederick W. Miller, David V. Gold, James A. Barbosa, Zuzana Fligiel |
Rok vydání: |
1980 |
Předmět: |
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Zdroj: |
JNCI: Journal of the National Cancer Institute. |
ISSN: |
1460-2105 |
DOI: |
10.1093/jnci/64.3.439 |
Popis: |
Cultured human colon carcinoma cells were induced by the polar solvent N,N-dimethylformamide (DMF) to express a more differentiated phenotype as indicated by three types of antigen markers. Carcinoembryonic antigen expression in all DMF-induced cell lines was enhanced. Exposure of cells to DMF resulted in a reduction in ability to bind antibody to tumor-derived colon mucoprotein antigen (CMA) with a concomitant gain in binding of antibody to normal CMA. DMF-induced differentiation was further indicated by modulation of blood group antigen expression. DMF treatment decreased the amount of expression of the H-gene determinant. When DMF-treated cells were cultured in the absence of DMF for 14 days, the levels of expression of the antigen markers reverted to those characteristic of their untreated counterparts. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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