Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy

Autor:	Thomas Auberger, Peter Lemmen, Detlev Gabel, Thomas U. Probst, Natalia G. Berryman, L. Weissfloch, Jörgen Carlsson, Börje Larsson
Rok vydání:	1997
Předmět:	Detection limit Analyte Radiochemistry Analytical chemistry chemistry.chemical_element Mass spectrometry Analytical Chemistry Neutron capture chemistry Inductively coupled plasma Microwave digestion Boron Inductively coupled plasma mass spectrometry Spectroscopy
Zdroj:	Journal of Analytical Atomic Spectrometry. 12:1115-1122
ISSN:	1364-5544 0267-9477
DOI:	10.1039/a700445a
Popis:	A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS and quantitative neutron capture radiography (QNCR). The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml–1 by ICP-AES and 0.3 ng ml–1 by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 µg ml–1 and 3 ng ml–1. The results of the spectrometric determinations were confirmed by QNCR of whole-body cryosections of six mice. A brief description of the metabolism of the boron compound is given.
Databáze:	OpenAIRE
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