Diffusive transport of drugs from film matrices

Autor:	R. Yu. Kosenko, A. L. Iordanskii, A. A. Ischenko, M. A. Gol’dshtrakh, A. A. Olkhov, V. S. Markin
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Aqueous solution General Chemical Engineering Diffusion Inorganic chemistry Kinetics Analytical chemistry General Chemistry Polymer Controlled release Hydrolytic degradation Reaction rate constant chemistry Uv spectrophotometry
Zdroj:	Theoretical Foundations of Chemical Engineering. 49:847-853
ISSN:	1608-3431 0040-5795
Popis:	The diffusion characteristics of poly(3-hydroxybutyrate)-based matrices for controlled release of an antiseptic (furacilin) are reported. The kinetics of furacilin release into aqueous solution from poly(3-hydroxybutyrate) matrices containing 0.5 to 5.0 wt % antiseptic has been investigated by UV spectrophotometry. The furacilin release curves indicate a combination of diffusion and kinetic processes. The diffusion component of the processes has been analyzed, the diffusion coefficients have been measured, and their concentration dependence has been elucidated. The release rate constant also depends on the furacilin content and is correlated with the hydrolytic degradation of the polymer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::735307ec8eec8829d32250e8db61bbea https://doi.org/10.1134/s0040579515060068 Zobrazit plný text záznamu Plný text ve formátu PDF