Adrenalectomy increases neurogenesis but not PSA-NCAM expression in aged dentate gyrus

Autor:	Klaus G. Petry, Michela \\'Micky\\' Marinelli, M. Le Moal, Geneviève Rougon, Marie-Françoise Montaron, C. Aurousseau, J. J. Rodriguez, Djoher Nora Abrous
Rok vydání:	1999
Předmět:	medicine.medical_specialty General Neuroscience Dentate gyrus Adrenalectomy medicine.medical_treatment Neurogenesis Hippocampus Biology chemistry.chemical_compound Endocrinology nervous system chemistry Corticosterone Internal medicine medicine Neural cell adhesion molecule Stem cell Progenitor cell
Zdroj:	European Journal of Neuroscience. 11:1479-1485
ISSN:	0953-816X
DOI:	10.1046/j.1460-9568.1999.00579.x
Popis:	Ageing is accompanied by a decline in neurogenesis and in polysialylated isoforms of neural cell adhesion molecule (PSA-NCAM) expression within the hippocampus and by elevated basal levels of circulating corticosterone. In a companion study, we demonstrated that suppression of corticosterone by adrenalectomy increased neurogenesis and PSA-NCAM expression in the dentate gyrus of adult rats. Here we show that adrenalectomy increased neurogenesis in this structure in old rats, as measured by the incorporation of 5-bromo-2′-deoxyuridine in neuronal progenitors. This effect was prevented by corticosterone replacement. In contrast, PSA-NCAM expression remained unchanged in comparison with controls. Thus, in the aged brain, stem cells are still present and able to enter the cell cycle. This may point to ways of protecting or treating age-related cognitive impairments.
Databáze:	OpenAIRE
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