Lupus néonatal : une fratrie de nouveau-nés avec différentes expressions cliniques

Autor:	Antonio Alberto Zuppa, G. De Rosa, F Visintini, Angelica Bibiana Delogu, Giuseppe Gio Batta Tortorolo, Daniele De Luca, Francesco Cota
Rok vydání:	2004
Předmět:	Pregnancy Systemic disease medicine.medical_specialty Pediatrics Lupus erythematosus Heart disease business.industry Autoantibody medicine.disease Connective tissue disease Surgery Pediatrics Perinatology and Child Health medicine Sibling business Rare disease
Zdroj:	Archives de Pédiatrie. 11:936-939
ISSN:	0929-693X
Popis:	Neonatal Lupus Syndrome is a rare disease caused by placental passage of maternal autoantibodies. Pathogenesis is partially unknown and many clinical manifestations are possible. We report on newborn siblings who presented with different symptoms of Neonatal Lupus Syndrome. One patient presented with congenital heart block and another with hepatic and haematologic involvement. Cases of Neonatal Lupus among siblings are very rare, because of the high risk of pregnancy in affected women. Various clinical expressions may be explained by a different specificity of Anti-Ro autoantibodies among siblings. The reported cases are commented with regard to recent literature, trying to explain their pathogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7340930169a8cd9a2a7ac79b862f2fc5 https://doi.org/10.1016/j.arcped.2004.05.009 Zobrazit plný text záznamu Full Text from ScienceDirect