ChemInform Abstract: The Synthesis of Novel Mimics of the Sialyl Lewis X Determinant

Autor:	Alan Hornsby Davidson, Fionna M. Martin, Christopher David Floyd, Nigel M. Allanson
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Ketone Nucleophilic addition Stereochemistry Disaccharide General Medicine Fucose Sialic acid carbohydrates (lipids) chemistry.chemical_compound Sialyl-Lewis X chemistry Lewis acids and bases Linker
Zdroj:	ChemInform. 26
ISSN:	0931-7597
DOI:	10.1002/chin.199518231
Popis:	Disaccharide mimics of the sialyl Lewis X (sLe x ) ligands have been prepared as potential antagonists of binding to the lectin domains of the E-selectin adhesion molecule. Versatile derivatives of sialic acid provide an entry to a series of simplified linker groups supporting the fucose and sialyl residues. The stereoselectivity of nucleophilic addition to the fucosyl ketone derivative 7 is determined by the conditions employed: basic and Lewis acid conditions give opposite results.
Databáze:	OpenAIRE
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