Synthesis of milbemycins from avermectins

Autor:	Alexander R Matzuk, Helmut Mrozik, M. H. Fisher, Mary F. Woods, John C. Chabala, F. S. Waksmunski, P. Eskola
Rok vydání:	1983
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Milbemycin Aglycone chemistry Stereochemistry Organic Chemistry Drug Discovery Chemical reduction Organic chemistry Biochemistry Lactone
Zdroj:	Tetrahedron Letters. 24:5333-5336
ISSN:	0040-4039
Popis:	The structure of the avermectins and the milbemycins were interrelated by the conversion of 22,23-dihydroavermectin B1a and B1b aglycones (4) into 13-deoxy-22,23-dihydroavermectin B1a aglycone (9) and 13-deoxy-22,23-dihydroavermectin B1b aglycone (11) corresponding to 26-ethyl milbemycin-α3 and milbemycin B-41D respectively via reduction of the protected 13-chloroaglycone derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::732fec8186a79d0d27394b4cc31abc69 https://doi.org/10.1016/s0040-4039(00)87861-2 Zobrazit plný text záznamu