Abstract P75: Cerebrovascular Events and Outcomes in Hospitalized Patients With Covid-19: The Society of Vascular and Interventional Neurology Multinational Registry

Autor: Luis San Roman, Juan F. Arenillas, A. Singla, I. Bach, Alba Chavarría-Miranda, Alicia Zha, Alexandra L Czap, Ameer E Hassan, P. Patel, N. P. De la Ossa, Diogo C Haussen, Ryna Then, O. O. Zaidat, David S Liebeskind, Jesse M. Thon, Santiago Ortega-Gutierrez, Xabi Urra, P. Khandelwal, Saif Bushnaq, Alejandro Vazquez, Marc Ribó, Dinesh V Jillella, Ossama Mansour, Thanh N. Nguyen, Mudassir Farooqui, Raul G Nogueira, Pere Cardona Portela, Artem Kaliaev, Manuel Requena, A. Guillen, Cristina Tiu, James E. Siegler, Mónica Millán, Tudor G Jovin, M. de Lera
Rok vydání: 2021
Předmět:
Zdroj: Stroke. 52
ISSN: 1524-4628
0039-2499
DOI: 10.1161/str.52.suppl_1.p75
Popis: Background: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aims: To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease. Methods: Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in 4 countries (2/1/2020 - 06/16/2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST). Results: Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970-1320/100,000), 68/171 (40.5%) of whom were female and 96/172 (55.8%) were between the ages 60-79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920-1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130 - 280/100,000) and 3 with CVST (0.02%; 20/100,000, 95%CI 4-60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p Conclusions: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19 associated cerebrovascular complications, therefore aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
Databáze: OpenAIRE
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