Associations between airway hyperresponsiveness, obesity and lipoproteins in a longitudinal cohort
| Autor: | Robert J. Hancox, Parameswaran Nair, Finn Rasmussen, Mads Nybo, Hans Christian Siersted, Henrik Steen Hansen |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty education.field_of_study business.industry Cholesterol Population respiratory system medicine.disease Obesity respiratory tract diseases chemistry.chemical_compound Endocrinology chemistry Internal medicine Cohort medicine Immunology and Allergy lipids (amino acids peptides and proteins) education business Body mass index Genetics (clinical) Asthma Cohort study Lipoprotein |
| Zdroj: | The Clinical Respiratory Journal. 7:268-275 |
| ISSN: | 1752-6981 |
| Popis: | Background Epidemiological data have linked obesity with an increased risk of asthma, but the mechanisms responsible for this relationship remain unknown. One possible mechanism, which has received little attention, could be the effect of cholesterol metabolism on airway smooth muscle function. The present study investigated the association between airway hyperresponsiveness (AHR) to methacholine and body mass index (BMI) and plasma lipoproteins [low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol]. Methods Associations between AHR, BMI and plasma lipoproteins were assessed in a population-based cohort at ages 14 and 20 years. Results In unadjusted analyses, higher LDL cholesterol levels at age 14 were associated with AHR at age 20 in both sexes (P |
| Databáze: | OpenAIRE |
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