Copper-mediated N-arylation of methyl 2-aminothiophene-3-carboxylate with organoboron reagents

Autor:	Gary A. Molander, Nasir Rasool, Drew R. Heitz, Muhammad Zubair, Komal Rizwan, Idris Karakaya
Rok vydání:	2015
Předmět:	Potassium Organic Chemistry Copper mediated chemistry.chemical_element Biochemistry Combinatorial chemistry Copper chemistry.chemical_compound chemistry Reagent Drug Discovery Thiophene Organic chemistry Amine gas treating Carboxylate
Zdroj:	Tetrahedron Letters. 56:6839-6842
ISSN:	0040-4039
Popis:	A practical protocol for the synthesis of N-arylated methyl 2-aminothiophene-3-carboxylate has been developed via Chan-Lam cross-coupling. The desired products were synthesized by cross-coupling of methyl 2-aminothiophene-3-carboxylate with both arylboronic acids and potassium aryltrifluoroborate salts in moderate to good yields. A broad range of functional groups was well tolerated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7328ba7af5ca8a131937593ffc870d0c https://doi.org/10.1016/j.tetlet.2015.10.080 Zobrazit plný text záznamu Full Text from ScienceDirect