| Popis: |
The key intermediate, 5-(p-chloropheny1)-1H-pyrazole-3-carboxylic acid hydrazide (3),was used for the synthesis of some new hydrazones 8a-g as well as some five membered heterocyclic derivatives such as pyrazoles 10, 11a,b, 12, pyrrole 13, 1,3,4-Oxadiazole 15, 1,2,4-triazole 17 and 1,3,4-thiadiazole 19. Identification of the new compounds was substantiated by spectral data and elemental analysis .Compound 6f which has a sulfadiazine moiety linked to the pyrazole showed a powerful anti-inflammatory activity than diclofenac sodium. |
