Clinical and survival characteristics of patients with BRAF-mutated metastatic colorectal cancer (mCRC) who receive metastases surgery in a Spanish cohort

Autor: Javier Soto, Marianela Bringas, Natalia Gutiérrez Alonso, Andrés J. Muñoz Martín, Aitana Calvo Ferrándiz, Gabriela Torres Pérez-Solero, Laura Ortega, Rocío Martín Lozano, Roberto Jiménez Rodríguez, Irene Gonzalez Caraballo, Carlos López Jiménez, Ana Gutierrez Ortiz de la Tabla, David Salomon Juliao Caamaño, Marc Ariant Cañete Muñoz, Mónica Benavente de Lucas, María Palma Gómez, Manuel Alva Bianchi, Íñigo Martínez Delfrade, Miguel Martin, Pilar Garcia-Alfonso
Rok vydání: 2023
Předmět:
Zdroj: Journal of Clinical Oncology. 41:66-66
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2023.41.4_suppl.66
Popis: 66 Background: Patients with mCRC harboring BRAF mutation have worse prognosis and poor outcomes. However, those who have resectable metastatic disease and undergo surgery may have better outcomes compared to those who do not. Differences in clinical characteristics are not well known and may be critical to identify patients with better prognosis. Methods: We performed a retrospective analysis of 299 patients with mCRC in a tumor registry from 2015 to 2021. We compared the clinical characteristics and survival trends of both cohorts (BRAF mutated and BRAF wild type). Furthermore, we analyzed clinical and survival features of 23 patients with BRAF mutated mCRC who received metastases resection. Results: We identified 34 patients with BRAF mutation (11.37%). Several characteristics were significantly more frequent in this group: age
Databáze: OpenAIRE
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