Characterization of pancreatic beta-cell receptors binding sulfanilamide drugs

Autor:	Savel'eva Mp, Balabolkin Mi, Babichev Vn
Rok vydání:	1994
Předmět:	Glibenclamide Dissociation constant Biochemistry Chemistry Endocrinology Diabetes and Metabolism medicine Gliclazide Sulfanilamide Binding site Beta cell Receptor medicine.drug Glipizide
Zdroj:	Problems of Endocrinology. 40:47-50
ISSN:	2308-1430 0375-9660
DOI:	10.14341/probl12194
Popis:	Analysis of pancreatic beta-cell receptors binding the sulfanilamide drugs widely used in therapy of type II diabetes, such as glybenclamide, glypizide, and glyclazide, showed that these drugs are characterized by excellent parameters of specific binding to these receptors. The receptors were tested for two parameters: number of binding sites and dissociation constant. Glybenclamide was the most active of the drugs we tested, the other two agents being less active. Binding of these agents was reversible. The problem of identification of the examined receptors of sulfanilamides with K+-ATP-sensitive channels, similarly active conductors of the information transported by the sulfanilamide drugs in the mechanism of insulin secretion, is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7322bb053353ce759c019c57f110ac36 https://doi.org/10.14341/probl12194 Zobrazit plný text záznamu