Sympathetic Neural Response to Immune Signals Involves Nitric Oxide
| Autor: | Zehava Gottesfeld |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Health (social science) Lipopolysaccharide Inflammation General Medicine Biology Toxicology Biochemistry Nitric oxide Behavioral Neuroscience Autonomic nervous system chemistry.chemical_compound Endocrinology Immune system medicine.anatomical_structure Neurology chemistry Immunity Internal medicine Immunopathology Immunology medicine medicine.symptom |
| Zdroj: | Alcohol. 16:177-181 |
| ISSN: | 0741-8329 |
| Popis: | In response to infection, inflammation, or injury, the neural–immune–endocrine networks are activated to restore or maintain stability in the internal environment. Disruption of any one of the functional components may impair the effectiveness of the immune response to challenges, and may consequently jeopardize the wellness of the host. Studies in the author’s laboratory have shown that the normal activation of splenic sympathetic neurons in response to the endotoxin lipopolysaccharide, a tool frequently used to mimic infection or inflammation, does not occur in fetal alcohol-exposed (FAE) rats. The sympathetic innervation of lymphoid organs is considered an important immune modulator. Thus, the anomalous splenic sympathetic response may partly account for the impaired immunity associated with FAE. Although the underlying mechanism is far from clear, studies described in this report suggest that nitric oxide (NO), a gaseous free radical, is involved in the altered splenic sympathetic neural response to immune signals. The suggestion is supported by the following findings: (1) blockade of NO synthesis prevented the blunted sympathetic response to lipopolysaccharide or interleukin-1 in FAE rats, and (2) there was a further increase in NO formation in response to lipopolysaccharide in the FAE rats compared to their control cohorts. This was demonstrated by an augmented increase in the inducible NO synthase immunoreactivity in the spleen as well as in circulating levels of NO metabolites. It is suggested, therefore, that the altered splenic sympathetic response to immune signals involves excessive formation of NO that may account, at least in part, for the impaired immunity associated with FAE. |
| Databáze: | OpenAIRE |
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