| Popis: |
Except for the report of a case of atophan hepatitis by Worster-Drought1in 1923 and a fatal case of liver atrophy due to Weldona tablets demonstrated by Cabot2in 1925, actual knowledge of the toxic effect of cinchophen preparations on the liver dates from 1926. In a little more than four years, forty-one cases have been reported. Including my two cases previously reported and seven cases presented here, there is a total of fifty cases with twenty-five deaths and twenty autopsies, confirming the diagnosis of toxic hepatitis and liver atrophy as the cause of death. It is highly probable that many cases have not been reported, and that many more cases of jaundice and liver atrophy would on careful investigation prove to be due to the previous use of the drug in one of its forms. This has been amply demonstrated by my own experience. The association of |
