Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions
| Autor: | Lihong Hu, Fanglei Chen, Min Lei |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Synthesis. 46:3199-3206 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/s-0034-1378659 |
| Popis: | A series of C-10-substituted tabersonine analogues have been synthesized via palladium-catalyzed cross-coupling reactions. To be specific, tabersonine reacted with NIS in TFA to generate the 10-iodotabersonine, which participated in palladium-catalyzed or palladium/copper co-catalyzed cross-coupling reactions, such as Suzuki–Miyaura cross-coupling reaction, Heck reaction, and Sonogashira cross-coupling reaction, to afford C-10 tabersonine analogues. These protocols provide the possibility of introducing substituents with structural diversity and complexity into the C-10 of tabersonine for the pharmacological activity screening. |
| Databáze: | OpenAIRE |
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