Pharmacological evaluation of UK-14,304 analogs at cloned human α adrenergic receptors

Autor:	Chi Luo, Carlos Forray, Charles Gluchowski, Pierre J.-J. Vaysse, Jeon Yoon T, Theresa Branchek
Rok vydání:	1995
Předmět:	α2 agonists α adrenergic receptors Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Subtype selective Biochemistry Receptor subtype Drug Discovery Molecular Medicine Molecular Biology Binding affinities
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:2255-2258
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00391-6
Popis:	As a part of a program directed at the identification of subtype selective α2 agonists, a series of analogs of UK-14,304 (1) were synthesized. Binding affinities and functional efficacies were measured at cloned human α adrenergic receptors. A number of analogs showed high binding affinity and good selectivity for the human α2A receptor subtype.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7314d97d90c88062498c168785d9b5b8 https://doi.org/10.1016/0960-894x(95)00391-6 Zobrazit plný text záznamu Full Text from ScienceDirect