Asymmetric Darzens-Type Epoxidation via Chiral Ammonium Ylides

Autor:	Hiroyo Kinoshita, Tetsutaro Kimachi, Akiko Ihoriya, Motoharu Ju-ichi
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Brucine chemistry Transfer agent Tertiary amine Aryl Organic Chemistry Epoxide Darzens reaction Ammonium Chirality (chemistry) Medicinal chemistry
Zdroj:	Synlett. 2010:2330-2334
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0030-1258015
Popis:	Asymmetric Darzens-type epoxide formation of aryl aldehydes with chiral para-substituted benzylammonium ylides, prepared from brucine and corresponding benzylic chlorides and treated in situ under basic condition, was carried out to afford chiral 2,3-diaryl epoxides with moderate to good ee (84% ee). Brucine was found to be an excellent tertiary amine for a chirality transfer agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::73131c7be0507ddf6b5809622356d010 https://doi.org/10.1055/s-0030-1258015 Zobrazit plný text záznamu