PREGNANCY OUTCOMES AFTER EXPOSURE TO TNF-α INHIBITORS FOR THE TREATMENT OF ARTHRITIC DISEASES: A META-ANALYSIS OF OBSERVATIONAL STUDIES
| Autor: | Kamelia Mirdamadi, Micheline Piquette-Miller, Manny Papadimitropoulos, Tim Salinas, Reza Vali |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty education.field_of_study Pregnancy business.industry Birth weight Population Gestational age Odds ratio medicine.disease 030226 pharmacology & pharmacy 03 medical and health sciences Low birth weight 030104 developmental biology 0302 clinical medicine Internal medicine medicine Gestation medicine.symptom education business Live birth |
| Zdroj: | Journal of Population Therapeutics and Clinical Pharmacology. 25:e53-e56 |
| ISSN: | 1710-6222 1198-581X |
| DOI: | 10.22374/1710-6222.25.1.5 |
| Popis: | Title: Pregnancy Outcomes after Exposure to TNF-α Inhibitors During Pregnancy for the Treatment of Arthritic Diseases: A Meta-Analysis Authors: Mirdamadi K, Salinas T, Vali R, Papadimitripulous M, Piquette-Miller M Background: Auto-immune arthritic diseases affect many women of child-bearing age. Tumor necrosis factor (TNF)-α inhibitors are currently used for the treatment of various immune-mediated diseases during pregnancy. However, there has been no evaluation of safety in the treatment of arthritic diseases during gestation. Objective: To analyze the risk of adverse pregnancy and neonatal outcomes after treatment of arthritic diseases with TNF-α inhibitors. Methods: Major databases including Ovid MEDLINE, Embase, and Web of Science, were searched inclusive to April 2016. Observational prospective cohort studies evaluating pregnancy outcomes after exposure to TNF-α inhibitors for the treatment of arthritic diseases during pregnancy were included. Data on pregnancy and neonatal outcomes was extracted from all included studies. A meta-analysis was performed using inverse-variance random effect with a 95% confidence interval (95%CI) and p |
| Databáze: | OpenAIRE |
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