ChemInform Abstract: An Efficient Method for the Preparation of 3-Hydroxyl-5-substituted 2-Pyrrolidones and Application in the Divergent Synthesis of (-)-Preussin and Its Analogues

Autor:	Xiao-Yun Wei, Bang-Guo Wei, You-Qin Li, Qian-Ru Zhou, Danfeng Huang
Rok vydání:	2014
Předmět:	Antifungal chemistry.chemical_classification Aldimine chemistry medicine.drug_class Reagent Block (telecommunications) medicine Organic chemistry General Medicine Divergent synthesis Combinatorial chemistry Pyrrole derivatives
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201451211
Popis:	An asymmetric method to ( S , R )-α-hydroxyl-γ-amino alcohols 12 through a diastereoselective addition of Grignard reagents to β-chiral aldimines 11 is described. Subsequent oxidation/cyclization with Sarett reagent provided a novel approach to lactams 14 , a flexible building block whose utility was demonstrated in the divergent synthesis of antifungal agent (−)-preussin 5 and its three analogues 23 , 24 , 25 .
Databáze:	OpenAIRE
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