SAT0604 Secondary hemophagocytic syndrome: retrospective study according to the underlying disease
| Autor: | L.M. López, E. Uriarte, M.M. Yagüe, J.R. Furundarena, C.A. Egües Dubuc, J. Cancio, A. De Diego, J. Belzunegui, O. Maíz, J.A. Valero, J. Calvo Alén |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Retrospective cohort study Still Disease Disease medicine.disease Pancytopenia Organomegaly 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Rheumatoid arthritis Internal medicine Biopsy medicine Hemophagocytosis medicine.symptom business |
| Zdroj: | Saturday, 16 JUNE 2018. |
| DOI: | 10.1136/annrheumdis-2018-eular.6184 |
| Popis: | Background Secondary Hemophagocytic Syndrome (SHS) is associated with Hematoncologic (HO), Autoimmune (AI) diseases [such as Systemic Lupus Erythematosus (SLE) or Adult’s Still Disease (ASD)] and in a lower frequency with Infections (Inf.) and Tumours (Tum.). Objectives Describe the demographic and underlying disorders during hospital admission of patients with SHS during the period December/2005-January/2018. Methods A retrospective search of patients diagnosed with SHS and bone marrow biopsy (B.M.O.) with hemophagocytosis was performed. Patients were grouped in: AI, HO, Inf, Tum. and SHS without cause (wc). The variables were: sex, age, diagnosis of the underlying disease, fever, organomegaly, laboratory findings, days of hospital stay, days from admission to B.M.O. and mortality. Results A total of 27 patients were found. table 1 shows the characteristics of the groups. AI xxdiseases found were: 5 SLE, 2 ASD, 1 Rheumatoid Arthritis and 1 Sclerosing Disease Related to IgG4. The HOs were: 4 Myelodysplastic Syndrome, 3 Non-Hogkins Lymphomas, 2 Acute Leukemias, 1 Extranodal Lymphoma of Natural Killer Cells (NKC) and 1 Gastric Plasmocytoma. Inf. were: 1 infection of Pneumocystis in the recent diagnosis of HIV and Gastroenteritis by Campylobacter yeyuni. One Tum. in a patient with Glioblastoma multiforme who received temozolomide. During the follow-up no recurrence of SHS was observed. The sCD25 and cytolytic activity of the NKC were not done. Conclusions Patients with SHS to HO disease had a high mortality and a longer hospital stay compared to the rest of the groups. Practically all patients met all diagnostic criteria, the most frequent were fever, pancytopenia and hyperferritinemia. Disclosure of Interest None declared |
| Databáze: | OpenAIRE |
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