Lipid-lowering and antioxidative effects ofApium graveolensL. root flavonoid extracts
| Autor: | Airong Zhang, Sun Jing, Yang Shi, Li Tian, Xiaoxia Zhang, Yuan He |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Serum lipid levels Chemistry Cholesterol General Chemical Engineering medicine.medical_treatment Flavonoid Apium graveolens 02 engineering and technology General Chemistry Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences 0104 chemical sciences Sterol regulatory element-binding protein chemistry.chemical_compound Hyperlipidemia medicine lipids (amino acids peptides and proteins) Lipid lowering 0210 nano-technology |
| Zdroj: | RSC Advances. 9:26757-26767 |
| ISSN: | 2046-2069 |
| Popis: | Flavonoids are the major components of Apium graveolens L. root (AR). In this study, we used a rat model of high-fat emulsion die induced hyperlipidemia (HLP) to examine the antioxidant and lipid-lowering effects of the AR flavonoid extract (ARFE), and to identify its potential targets by molecular docking and western-blotting. ARFE significantly lowered the serum lipid levels in HLP rats. The lipid-lowering targets of ARFE were predicted and validated, which showed that ARFE significantly downregulated the expression levels of cholesterol synthesis-associated target proteins, including SREBP1, HMGCR and ACC1. These findings demonstrate that ARFE has remarkable lipid-lowering and antioxidant effects, and the former is mediated by the inhibition of SREBP1, HMGCR and ACC1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|