Comparison of Two Formulations of Cyclosporin A in the Treatment of Severe Atopic Dermatitis

Autor:	M.K. Kägi, B. Zurbriggen, P.B. Wili, A.B. Cachelin, B. Wüthrich
Rok vydání:	1999
Předmět:	medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Dermatology Atopic dermatitis Ciclosporin medicine.disease Gastroenterology Tolerability Pharmacokinetics Oral administration Cyclosporin a Internal medicine medicine Onset of action business medicine.drug
Zdroj:	Dermatology. 198:56-60
ISSN:	1421-9832 1018-8665
Popis:	Background: Cyclosporin A (CsA) has been shown to be highly effective in the therapy of atopic dermatitis (AD). However, little information exists on the treatment of AD patients with Sandimmun Neoral® (Neoral), a microemulsion of CsA with improved pharmacokinetic properties in comparison to Sandimmun®. Objective: We have compared the efficacy and tolerability of Sandimmun and Neoral. Methods: In a randomised, monocentric, double-blind, cross-over pilot study (n = 14), each formulation was administered for 8 weeks, followed by switching to the other treatment group for another 8 weeks. Results: After 2 weeks of therapy, the improvement under Neoral therapy was significantly higher than with Sandimmun (disease activity p = 0.047; extent of disease p = 0.016). In contrast, after 8 weeks of therapy, both formulations yielded similar improvement in the patients’ condition. Conclusion: While both formulations are effective and well tolerated in the treatment of severe AD, Neoral may have a faster onset of action and higher initial efficacy, which makes it an adequate replacement for Sandimmun.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72e3f0a99a1eb62bf05ee1afae951958 https://doi.org/10.1159/000018065 Zobrazit plný text záznamu