Histopathological changes in the pancreas of laboratory rats

Autor:	G. Kendrey, F. J. C. Roe
Rok vydání:	1969
Předmět:	Pathology medicine.medical_specialty General Veterinary business.industry Connective tissue medicine.disease Peripheral blood mononuclear cell Epithelium medicine.anatomical_structure Basophilia Fibrosis medicine Etiology Animal Science and Zoology business Pancreas Infiltration (medical)
Zdroj:	Laboratory Animals. 3:207-220
ISSN:	1758-1117 0023-6772
Popis:	'Chronic relapsing pancreatitis' was seen in 81 per cent of 108 rats of 3 inbred strains. Clinically, even in advanced cases, there were no symptoms of disease and the physical status of the animals was satisfactory. The least histological sign of involvement was a decrease or loss of cytoplasmic basophilia in acinar cells in some lobules, and infiltration of the intralobular connective tissue by mononuclear cells. More severe forms of the disease were characterized by flattening of the epithelium of acini by 'microcystic-transformation' of the gland, and fatty atrophy. Fibrosis of the connective tissue and dilatation of the ducts were usual events. In few cases 'polyarteritis-like' lesions of the arteries of the pancreas were observed. Microbiological investigation of the aetiology is in progress.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72de28a2d5a7eebb0bf002598178bb19 https://doi.org/10.1258/002367769781071844 Zobrazit plný text záznamu