Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O,N) donor bidentate ligands
| Autor: | Alexander Roller, Michael A. Jakupec, Krisztina Bali, Michaela Hejl, Bernhard K. Keppler, Carmen M. Hackl, Wolfgang Kandioller, Orsolya Dömötör, Éva A. Enyedy |
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| Rok vydání: | 2017 |
| Předmět: |
Aqueous solution
Denticity medicine.diagnostic_test 010405 organic chemistry Ligand Stereochemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Chloride 0104 chemical sciences Rhodium Inorganic Chemistry chemistry Spectrophotometry Materials Chemistry medicine Proton NMR Moiety Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Journal of Organometallic Chemistry. 846:287-295 |
| ISSN: | 0022-328X |
| Popis: | Complex formation processes of the (O,N) donor ligands 6-methylpicolinic acid (6-Mepic), quinoline-2-carboxylic acid (2-QA) and 3-isoquinolinecarboxylic acid (3-iQA) with the organometallic moiety (η 5 -pentamethylcyclopentadienyl)rhodium(III) (RhCp*) were studied in aqueous solution by the combined use of pH-potentiometry, 1 H NMR spectroscopy and UV-Vis spectrophotometry. The solid phase structures of the [RhCp*(L)Cl] complexes bearing 6-Mepic and 2-QA were characterized by single-crystal X-ray diffraction analysis. Studies revealed the exclusive formation of mono complexes of the form [RhCp*(L)(H 2 O)] + (L = deprotonated form of the ligands) and [RhCp*(L)(OH)]. The positively charged aqua species predominate at physiological pH even in the micromolar concentration range. The H 2 O/Cl − co-ligand exchange constants showed that all complexes preferably retain the chlorido ligand at the third coordination site at chloride ion concentrations present in the serum. In addition in vitro cytotoxicity of these [RhCp*(L)Cl] complexes was evaluated in three human cancer cell lines (A549, SW480 and CH1/PA-1) where they showed minor cytotoxic potency. |
| Databáze: | OpenAIRE |
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