Elucidating the molecular mechanisms of Mycobacterium avium subsp. paratuberculosis intracellular survival (618.7)

Autor:	LaCheyla Blount, Ashley Green, Elise A. Lamont, Carleitta Paige-Anderson, Srinand Sreevatsan
Rok vydání:	2014
Předmět:	Bacilli Stringent response Disease Biology biology.organism_classification Biochemistry Genome Microbiology Pathogenesis Immune system Genetics Dormancy Molecular Biology Gene Biotechnology
Zdroj:	The FASEB Journal. 28
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.28.1_supplement.618.7
Popis:	Johne’s Disease (JD), a wasting disease of ruminants, is of major concern within the agricultural and food defense industries. The etiological agent of JD is Mycobacterium avium subsp. paratuberculosis (MAP). MAP evades host-mediated immune responses, forming an environmental niche that supports bacterial growth, ‘containment’ of the infection, and metabolic dormancy. Latent bacilli can persist for long periods or through unclear mechanisms render disease. The MAP genome is closely related to other mycobacterial pathogens, particularly Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis disease, and has led to hypotheses on the contribution of various genes to MAP pathogenesis. Mechanisms underlying Mtb infection include the stringent response and iron acquisition. The stringent response is initiated by unfavorable environmental conditions and expression of the relA gene.Deleting relA in Mtb results in attenuation. During active growth, Mtb synthesizes carboxymycobactin, a secreted sider...
Databáze:	OpenAIRE
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