An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard

Autor:	A. S. Radilov, E. I. Savel’eva, N. L. Koryagina, A. I. Ukolov, N. S. Khlebnikova, M. D. Shachneva
Rok vydání:	2018
Předmět:	Detection limit Chemical ionization Chromatography Gas Chromatography/Tandem Mass Spectrometry Chemistry 010401 analytical chemistry Thio chemistry.chemical_element Sulfur mustard 01 natural sciences Sulfur 0104 chemical sciences Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mass spectrum 030216 legal & forensic medicine Gas chromatography–mass spectrometry
Zdroj:	Journal of Analytical Chemistry. 73:1269-1274
ISSN:	1608-3199 1061-9348
Popis:	Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::72ccd63915f52b0421f0e4b5353f5731 https://doi.org/10.1134/s1061934818130087 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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